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This course requires Windows Operating Systems (95/98, NT, 2000, ME, XP), version 5.5 browsers or higher from Microsoft or Netscape.

Certain activities may require additional software to view multimedia, presentation, or printable versions of the content. These activities will be marked as such and will provide links to the required software. That software may be: Macromedia Flash, Adobe Acrobat, Microsoft PowerPoint, Windows Media Player, and Real Networks Real One Player.

ACCREDITATION STATEMENT

This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the Elsevier Office of Continuing Medical Education (EOCME) and Excerpta Medica, Inc. The EOCME is accredited by the ACCME to provide continuing medical education (CME) for physicians.

CREDIT DESIGNATION STATEMENT

The EOCME designates this educational activity for a maximum of 0.5 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

DISCLOSURES

As a sponsor accredited by the ACCME, it is the policy of the EOCME to require the disclosure of anyone who is in a position to control the content of an educational activity. All relevant financial relationships with any commercial interests and/or manufacturers must be disclosed to participants at the beginning of each activity. The faculty of this CME activity disclose the following:

RESOLUTION OF CONFLICT OF INTEREST

The EOCME has implemented a process to resolve conflicts of interest for each CME activity. In order to help ensure content objectivity, independence, fair balance, and that the content is aligned with the interest of the public, the EOCME has resolved the conflict by conducting peer review.

UNAPPROVED/OFF-LABEL USE DISCLOSURE

The EOCME requires CME faculty to disclose to the participants:

1. When products or procedures being discussed are off-label, unlabeled, experimental, and/or investigational (not US Food and Drug Administration [FDA] approved); and

2. Any limitations on the information that is presented, such as data that are preliminary or that represent ongoing research, interim analyses, and/or unsupported opinion.

Faculty may discuss information about pharmaceutical agents that is outside of FDA-approved labeling. This information is intended solely for CME and is not intended to promote off-label use of these medications. If you have questions, contact the medical affairs department of the manufacturer for the most recent prescribing information.

INTENDED AUDIENCE

This activity has been developed for cardiologists, emergency department physicians, internists, hospitalists, and other health care providers who treat patients with ST-elevation myocardial infarction (STEMI) or utilize percutaneous coronary intervention (PCI) for cardiac reperfusion for acute coronary syndromes (ACS).

PROGRAM GOAL

The goal of this activity is to summarize the results of recent large anticoagulation trials in patients with STEMI and discuss how these data influenced the recent STEMI and PCI guidelines in order to evaluate and understand new guideline recommendations.

EDUCATIONAL OBJECTIVES

• Review STEMI trials that form the evidence base, which in turn, supports the current guidelines for treatment
• Contrast updated guidelines with previous guidelines and discuss rationale for the change
• Understand the role of pharmacologic intervention as part of the revised guidelines
• Discuss the development of routes of communication before the patient reaches the hospital and the development of institutional transfer protocols
• Explain why primary PCI, if available, is preferable over fibrinolysis, with the understanding that fibrinolysis remains a good option

FINANCIAL SUPPORT

This CME activity is supported by an educational grant from sanofi-aventis U.S.

CME PLANNING COMMITTEE

SPECIAL NEEDS

We encourage participation by all individuals. If you have any special needs, please contact Kelly Kramer at (908) 547-2182, or k.kramer@elsevier.com for assistance.