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HARDWARE AND SOFTWARE SPECIFICATIONS NEEDED TO VIEW SITE

This course requires Windows Operating Systems (95/98, NT, 2000, ME, XP), version 5.5 browsers or higher from Microsoft or Netscape.

Certain activities may require additional software to view multimedia, presentation, or printable versions of the content. These activities will be marked as such and will provide links to the required software. That software may be: Macromedia Flash, Adobe Acrobat, Microsoft PowerPoint, Windows Media Player, and Real Networks Real One Player.

ACCREDITATION STATEMENT

This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the Elsevier Office of Continuing Medical Education (EOCME) and Elsevier. The EOCME is accredited by the ACCME to provide continuing medical education (CME) for physicians.

CME CREDIT STATEMENT

The EOCME designates this educational activity for a maximum of 4.5 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

FACULTY DISCLOSURES

As a sponsor accredited by the ACCME, it is the policy of the EOCME to require the disclosure of anyone who is in a position to control the content of an educational activity. All relevant financial relationships with any commercial interests and/or manufacturers must be disclosed to participants at the beginning of each activity. The faculty of this educational activity discloses the following:

RESOLUTION OF CONFLICT OF INTEREST

The EOCME has implemented a process to resolve conflict of interest for each CME activity. In order to help ensure content objectivity, independence, and fair balance, and to ensure that the content is aligned with the interest of the public, the EOCME has resolved the conflict by external content review.

UNAPPROVED/OFF-LABEL USE DISCLOSURE

The EOCME requires CME faculty to disclose to the participants:

1. When products or procedures being discussed are off-label, unlabeled, experimental, and/or investigational (not US Food and Drug Administration [FDA] approved); and

2. Any limitations on the information that is presented, such as data that are preliminary or that represent ongoing research; interim analyses; and/or unsupported opinion.

Faculty may discuss information about pharmaceutical agents that is outside of FDA-approved labeling. This information is intended solely for CME and is not intended to promote off-label use of these medications. If you have questions, contact the medical affairs department of the manufacturer for the most recent prescribing information.

INTENDED AUDIENCE

This activity has been developed for internists, primary care physicians, surgeons, oncologists, and hospitalists.

PROGRAM GOAL

This CME activity discusses the use of low-molecular-weight heparin (LMWH) versus unfractionated heparin (UFH) for the initial treatment of venous thromboembolism (VTE) as well as the issue of duration of VTE prophylaxis and the risks and benefits of extended therapy. Authors examine the pharmacologic characteristics of the traditional anticoagulants, and discuss the potential role of newer agents for VTE treatment and prevention while explaining the differences between UFH, LMWHs, and bioequivalent agents.

EDUCATIONAL OBJECTIVES

After reading this publication and taking the test, participants should be able to:

• Describe the differences between UFH and LMWHs.
• Discuss bioequivalent LMWHs and their use.
• Explain prevention of VTE events postdischarge in high-risk patients.
• Discuss the potential role of newer agents for VTE prevention and treatment.

FINANCIAL SUPPORT

This CME activity is supported by an educational grant from sanofi-aventis U.S.

CONTENT DEVELOPMENT COMITTEE

Geno J. Merli, MD, FACP, Editor
Jawed Fareed, PhD
Walter P. Jeske, PhD
Alex C. Spyropoulos, MD, FACP, FCCP
Victor F. Tapson, MD
Jeanine M. Walenga, PhD
Jennifer DiBenedetto
Cindy H. Jablonowski, MA

CME CERTIFICATE INQUIRIES

For all CME certificate inquiries, please contact Sandy Bakos at s.bakos@elsevier.com for assistance.

SPECIAL NEEDS

We encourage participation by all individuals. If you have any special needs, please contact Vanessa Fendt at (908) 547-2067 or v.fendt@elsevier.com for assistance.